TY - JOUR
T1 - Identifying protein-protein interactions in somatic hypermutation
AU - Goodman, Myron F.
AU - Scharff, Matthew D.
PY - 2005/2/21
Y1 - 2005/2/21
N2 - Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent but change appears imminent. Here we comment on how, when, and why biochemistry is likely to emerge from the shadows and into the spotlight to elucidate how the somatic mutation of antibody variable (V) regions is generated.
AB - Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent but change appears imminent. Here we comment on how, when, and why biochemistry is likely to emerge from the shadows and into the spotlight to elucidate how the somatic mutation of antibody variable (V) regions is generated.
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U2 - 10.1084/jem.20050161
DO - 10.1084/jem.20050161
M3 - Review article
C2 - 15710655
AN - SCOPUS:14244269848
SN - 0022-1007
VL - 201
SP - 493
EP - 496
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 4
ER -