Identifying protein-protein interactions in somatic hypermutation

Myron F. Goodman, Matthew D. Scharff

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent but change appears imminent. Here we comment on how, when, and why biochemistry is likely to emerge from the shadows and into the spotlight to elucidate how the somatic mutation of antibody variable (V) regions is generated.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalJournal of Experimental Medicine
Issue number4
StatePublished - Feb 21 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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