TY - JOUR
T1 - Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus
AU - Redolfi, E.
AU - Montagna, C.
AU - Mumm, S.
AU - Affer, M.
AU - Susani, L.
AU - Reinbold, R.
AU - Hol, F.
AU - Vezzoni, P.
AU - Cimino, M.
AU - Zucchi, I.
PY - 1998/12
Y1 - 1998/12
N2 - We have identified and characterized a novel human gene (Nomenclature Committee of the Genome Database GDB-assigned symbol CXorf1) that maps to the long arm of the X chromosome in Xq27 between loci DXS369 and DXS181, approximately 2.5 Mb centromeric to the FMR1 gene. The CXorf1 gene is conserved in primates, cow, and horse but not in mouse and rat. Northern blot analysis revealed two transcripts, present in the brain and in the G361 melanoma cell line. In situ hybridization experiments performed on sections of human hippocampus showed a clear, uneven localization of the CXorf1 mRNA in specific subfields of this brain area. In particular, CXorf1 was localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammon's horn. CXorf1 is one of the first genes from this region to be characterized in detail and, on the basis of its chromosomal location and expression pattern, may have an important function in the brain.
AB - We have identified and characterized a novel human gene (Nomenclature Committee of the Genome Database GDB-assigned symbol CXorf1) that maps to the long arm of the X chromosome in Xq27 between loci DXS369 and DXS181, approximately 2.5 Mb centromeric to the FMR1 gene. The CXorf1 gene is conserved in primates, cow, and horse but not in mouse and rat. Northern blot analysis revealed two transcripts, present in the brain and in the G361 melanoma cell line. In situ hybridization experiments performed on sections of human hippocampus showed a clear, uneven localization of the CXorf1 mRNA in specific subfields of this brain area. In particular, CXorf1 was localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammon's horn. CXorf1 is one of the first genes from this region to be characterized in detail and, on the basis of its chromosomal location and expression pattern, may have an important function in the brain.
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U2 - 10.1089/dna.1998.17.1009
DO - 10.1089/dna.1998.17.1009
M3 - Article
C2 - 9881668
AN - SCOPUS:0032412435
SN - 1044-5498
VL - 17
SP - 1009
EP - 1016
JO - DNA and Cell Biology
JF - DNA and Cell Biology
IS - 12
ER -