Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder

Daphne Simeon, Orna Guralnik, Margaret Knutelska, Eric Hollander, James Schmeidler

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background: The purpose of this preliminary study was to investigate HPA axis function in dissociation. Methods: Nine subjects with DSM-IV depersonalization disorder (DPD), without lifetime Posttraumatic Stress Disorder (PTSD) or current major depression, were compared to nine healthy comparison (HC) subjects of comparable age and gender. Results: DPD subjects demonstrated significant hyposuppression to low-dose dexamethasone administration and significantly elevated morning plasma cortisol levels when covaried for depression scores, but no difference in 24-hour urinary cortisol excretion. Dissociation scores powerfully predicted suppression whereas depression scores did not contribute to the prediction. Conclusions: Primary dissociative conditions, such as depersonalization disorder, may be associated with a pattern of HPA axis dysregulation that differs from PTSD and merits further study.

Original languageEnglish (US)
Pages (from-to)793-795
Number of pages3
Issue number5
StatePublished - 2001
Externally publishedYes


  • Cortisol
  • Depersonalization
  • Dexamethasone
  • Dissociation
  • HPA axis
  • Suppression

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


Dive into the research topics of 'Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder'. Together they form a unique fingerprint.

Cite this