Hypopigmented variant of mycosis fungoides: Demography, histopathology, and treatment of seven cases

Eileen Lambroza, Steven R. Cohen, Robert Phelps, Mark Lebwohl, Irwin M. Braverman, Damian DiCostanzo

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Background: Hypopigmented macules have been described infrequently as a presenting form of mycosis fungoides (MF). Objective: This study was designed to clarify general characteristics of a hypopigmented MF variant. Methods: Seven new cases were investigated with the use of descriptive epidemiology techniques. Demographic parameters, histopathology, and treatment outcomes were analyzed. These data were combined with those from prior reports to develop a broad composite view of this disease process. Results: The median ages in our series were 36 years for disease onset and 39 years at biopsy diagnosis. All patients had brown or black skin. Histologic findings consistently showed a lack of epidermal atrophy and moderate to profound exocytosis. Treatment with PUVA induced rapid and complete repigmentation in six of seven patients. Conclusion: On the basis of our experience and a literature review, the hypopigmented variant of MF occurs in a younger population than typical forms of the disease and affects persons with dark skin almost exclusively. Microscopic features include lack of epidermal atrophy and moderate to extreme epidermotropism of infiltrating mononuclear cells. The treatment of choice appears to be PUVA.

Original languageEnglish (US)
Pages (from-to)987-993
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number6
StatePublished - Jun 1995
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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