Hyperthermia on immune regulation: A temperature's story

Hua Gang Zhang; Keyur Mehta; Patrice Cohen; Chandan Guha

doi:10.1016/j.canlet.2008.05.026

Hyperthermia on immune regulation: A temperature's story

Hua Gang Zhang, Keyur Mehta, Patrice Cohen, Chandan Guha

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory effect on different sensitive targets. Understanding these intrinsic mechanisms could bring new inspirations on the design of clinical trials combining local tumor hyperthermia with immunotherapy in cancer patients. This review will attempt to tell the story about the effect of temperature on immune regulation, with special emphasis on the clinical application of hyperthermia and the feasibility of combining it with immunotherapy in the clinic.

Original language	English (US)
Pages (from-to)	191-204
Number of pages	14
Journal	Cancer Letters
Volume	271
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.05.026
State	Published - Nov 28 2008

Keywords

Heat shock protein
Hyperthermia
Immunomodulation
Immunotherapy
Tumor vaccine

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2008.05.026

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title = "Hyperthermia on immune regulation: A temperature's story",

abstract = "Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory effect on different sensitive targets. Understanding these intrinsic mechanisms could bring new inspirations on the design of clinical trials combining local tumor hyperthermia with immunotherapy in cancer patients. This review will attempt to tell the story about the effect of temperature on immune regulation, with special emphasis on the clinical application of hyperthermia and the feasibility of combining it with immunotherapy in the clinic.",

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AU - Mehta, Keyur

AU - Cohen, Patrice

AU - Guha, Chandan

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AB - Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory effect on different sensitive targets. Understanding these intrinsic mechanisms could bring new inspirations on the design of clinical trials combining local tumor hyperthermia with immunotherapy in cancer patients. This review will attempt to tell the story about the effect of temperature on immune regulation, with special emphasis on the clinical application of hyperthermia and the feasibility of combining it with immunotherapy in the clinic.

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KW - Immunomodulation

KW - Immunotherapy

KW - Tumor vaccine

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Hyperthermia on immune regulation: A temperature's story

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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