@article{735189914c2d49d3977dff6a6cc38e28,
title = "Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets",
abstract = "Cassetta et al. identify a breast cancer tumor-associated macrophage (TAM) transcriptome that is different from those of monocytes and tissue-resident macrophages, and which is associated with shorter disease-specific survival, and they demonstrate crosstalk between tumor cells and TAMs via SIGLEC1, CCL8, and CSF1.",
keywords = "CCL8, SIGLEC1, breast cancer, endometrial cancer, human circulating monocytes, human macrophages, tumor microenvironment",
author = "Luca Cassetta and Stamatina Fragkogianni and Sims, {Andrew H.} and Agnieszka Swierczak and Forrester, {Lesley M.} and Hui Zhang and Soong, {Daniel Y.H.} and Tiziana Cotechini and Pavana Anur and Lin, {Elaine Y.} and Antonella Fidanza and Martha Lopez-Yrigoyen and Millar, {Michael R.} and Alexandra Urman and Zhichao Ai and Spellman, {Paul T.} and Hwang, {E. Shelley} and Dixon, {J. Michael} and Lisa Wiechmann and Coussens, {Lisa M.} and Smith, {Harriet O.} and Pollard, {Jeffrey W.}",
note = "Funding Information: This research was supported by Wellcome Trust ( 101067/Z/13/Z ), MRC Center grant MR/N022556/1 , and NIH grant PO1 CA100324 to J.W.P., Department of Defense Breast Cancer Research Program ( W81XWH-111-0702 ) to L.M.C. and J.W.P., Susan G Komen Breast Cancer Foundation ( KG111084 and KG110560 ) to E.S.H. and L.M.C., from Breast Cancer Now to A.H.S. and J.M.D., from CONACYT to M.L.-Y. and Wellcome Trust ( 102610 ) to A.S. The work was supported extensively by the Edinburgh Breast Unit Team , and particularly by Lorna Renshaw and Jane Keys in this unit and the Departments of Gynecological and Surgical Oncology at the Montefiore Medical Center. We would like to thank the CIR blood resource (AMREC no. 15-HV-013) for the recruitment of blood from normal controls and the CIR flow facility (Shonna Johnston, Will Ramsay, and Mari Pattinson). We thank Dr Dahlia Doughty Shenton and the EPAC lab for InCucyte access. We thank Dr. Samanta A. Mariani for the scientific discussions and suggestions. We thank all the patients and volunteers who contributed to this study as well as all the clinical support teams. Funding Information: This research was supported by Wellcome Trust (101067/Z/13/Z), MRC Center grant MR/N022556/1, and NIH grant PO1 CA100324 to J.W.P. Department of Defense Breast Cancer Research Program (W81XWH-111-0702) to L.M.C. and J.W.P. Susan G Komen Breast Cancer Foundation (KG111084 and KG110560) to E.S.H. and L.M.C. from Breast Cancer Now to A.H.S. and J.M.D. from CONACYT to M.L.-Y. and Wellcome Trust (102610) to A.S. The work was supported extensively by the Edinburgh Breast Unit Team, and particularly by Lorna Renshaw and Jane Keys in this unit and the Departments of Gynecological and Surgical Oncology at the Montefiore Medical Center. We would like to thank the CIR blood resource (AMREC no. 15-HV-013) for the recruitment of blood from normal controls and the CIR flow facility (Shonna Johnston, Will Ramsay, and Mari Pattinson). We thank Dr Dahlia Doughty Shenton and the EPAC lab for InCucyte access. We thank Dr. Samanta A. Mariani for the scientific discussions and suggestions. We thank all the patients and volunteers who contributed to this study as well as all the clinical support teams. Conceptualization, L.C. S.F. L.M.C. H.O.S. and J.W.P.; Methodology, L.C. S.F. and J.W.P.; Writing – Original Draft, L.C. S.F. and J.W.P.; Writing – Review & Editing, L.C. S.F. L.M.C. and J.W.P.; Formal Analysis, L.C. S.F. D.Y.H.S. P.A. and P.T.S.; Investigation, L.C. S.F. D.Y.H.S. L.M.F. H.Z. A.S. E.Y.L. T.C. A.F. M.L.-Y. M.R.M. and Z.A.; Resources, L.M.F. L.W. E.S.H. H.O.S. A.U. and J.M.D.; Data Curation, S.F. A.H.S. and D.Y.H.S.; Visualization, S.F. L.C. L.M.C. and J.W.P.; Supervision, J.W.P. and A.H.S.; Project Administration, J.W.P.; Funding Acquisition, L.M.C. E.S.H. A.H.S. J.M.D. A.S. M.L.-Y. and J.W.P. All the authors declare that they have no financial interests. L.M.C. is a paid consultant for Cell Signaling Technologies, received reagent and/or research support from Plexxikon, Deciphera Pharmaceuticals, Pharma, and NanoString Technologies, and is a member of the Scientific Advisory Boards of Syndax Pharmaceuticals, Carisma Therapeutics, and Verseau Therapeutics. L.C. S.F. and J.W.P. are applying for patent protection for data contained in the paper and L.C. and J.W.P. have formed a company in order to exploit these patents. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = apr,
day = "15",
doi = "10.1016/j.ccell.2019.02.009",
language = "English (US)",
volume = "35",
pages = "588--602.e10",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}
