TY - JOUR
T1 - Human Leukocyte Antigen Class I and II Alleles and Risk of Cervical Neoplasia
T2 - Results from a Population-Based Study in Costa Rica
AU - Wang, S. S.
AU - Wheeler, C. M.
AU - Hildesheim, A.
AU - Schiffman, M.
AU - Herrero, R.
AU - Bratti, M. C.
AU - Sherman, M. E.
AU - Alfaro, M.
AU - Hutchinson, M. L.
AU - Morales, J.
AU - Lorincz, A.
AU - Burk, R. D.
AU - Carrington, M.
AU - Erlich, H. A.
AU - Apple, R. J.
N1 - Funding Information:
Financial support: Public Health Service (PHS) contracts N01CP21081 and N01CP31061 between the National Cancer Institute (NCI), theNational Institutes of Health, the Department of Health and Human Services, and FUCODOCSA (Costa Rican Foundation for Training in Health Sciences), Caja Costarricense de Seguro Social, Costa Rica; National Institutes of Health grants CA-78527 (to R.D.B.) and AI/CA-32917 (for study support and to C.M.W.).
PY - 2001/11
Y1 - 2001/11
N2 - To examine human leukocyte antigen (HLA) involvement in the development of all grades of cervical neoplasia, a nested case-control study of 10,077 women in Guanacaste, Costa Rica, was conducted. Participants had invasive cervical cancer, high-grade squamous intraepithelial lesions (HSILs; n=166), or low-grade squamous intraepithelial lesions (LSILs); were positive for human papillomavirus (HPV) with no evidence of cervical neoplasia (n=320); or were HPV negative with no evidence of cervical neoplasia but with a history of high-risk sexual behavior (n=173). Compared with women who were HPV negative, women with HLA-DRB1*1301 were associated with decreased risk for cancer/HSILs (odds ratio [OR], 0.4; 95% confidence interval [CI], 0.2–0.7) and for LSILs/HPV (OR, 0.6; 95% CI, 0.3–0.9). Women with both HLA-B*07 and HLA-DQB1*0302 had an 8.2-fold increased risk for cancer/HSILs (95% CI, 1.8–37.2) and a 5.3-fold increased risk for LSILs/HPV (95% CI, 1.2–23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection.
AB - To examine human leukocyte antigen (HLA) involvement in the development of all grades of cervical neoplasia, a nested case-control study of 10,077 women in Guanacaste, Costa Rica, was conducted. Participants had invasive cervical cancer, high-grade squamous intraepithelial lesions (HSILs; n=166), or low-grade squamous intraepithelial lesions (LSILs); were positive for human papillomavirus (HPV) with no evidence of cervical neoplasia (n=320); or were HPV negative with no evidence of cervical neoplasia but with a history of high-risk sexual behavior (n=173). Compared with women who were HPV negative, women with HLA-DRB1*1301 were associated with decreased risk for cancer/HSILs (odds ratio [OR], 0.4; 95% confidence interval [CI], 0.2–0.7) and for LSILs/HPV (OR, 0.6; 95% CI, 0.3–0.9). Women with both HLA-B*07 and HLA-DQB1*0302 had an 8.2-fold increased risk for cancer/HSILs (95% CI, 1.8–37.2) and a 5.3-fold increased risk for LSILs/HPV (95% CI, 1.2–23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection.
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U2 - 10.1086/324209
DO - 10.1086/324209
M3 - Article
C2 - 11679920
AN - SCOPUS:0035889999
SN - 0022-1899
VL - 184
SP - 1310
EP - 1314
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -