How a single protein complex accommodates many different H/ACA RNAs

Research output: Contribution to journalShort surveypeer-review

47 Scopus citations


More than 100 mammalian H/ACA RNAs form an equal number of ribonucleoproteins (RNPs) by associating with the same four core proteins. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes. Recent crystal structures of archaeal H/ACA protein complexes show how the same four proteins accommodate >100 distinct but related H/ACA RNAs and reveal that a spatial mutation cluster underlies dyskeratosis congenita, a syndrome of bone marrow failure.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalTrends in Biochemical Sciences
Issue number6
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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