HLA-B*07 is a high risk allele for familial cervical cancer

Xiaoping Qiu; Fan Zhang; Dangxiao Chen; Abul Kalam Azad; Li Zhang; Yulin Yuan; Zhongqing Jiang; Wenhui Liu; Yun Tan; Ning Tao

HLA-B^*07 is a high risk allele for familial cervical cancer

Xiaoping Qiu, Fan Zhang, Dangxiao Chen, Abul Kalam Azad, Li Zhang, Yulin Yuan, Zhongqing Jiang, Wenhui Liu, Yun Tan, Ning Tao

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B^*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B^*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.

Original language	English (US)
Pages (from-to)	2597-2600
Number of pages	4
Journal	Asian Pacific Journal of Cancer Prevention
Volume	12
Issue number	10
State	Published - 2011
Externally published	Yes

Keywords

Allele
Cervical cancer
Familial risk
HLA
Haplotype

ASJC Scopus subject areas

Epidemiology
Oncology
Public Health, Environmental and Occupational Health
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "HLA-B*07 is a high risk allele for familial cervical cancer",

abstract = "Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.",

keywords = "Allele, Cervical cancer, Familial risk, HLA, Haplotype",

author = "Xiaoping Qiu and Fan Zhang and Dangxiao Chen and Azad, {Abul Kalam} and Li Zhang and Yulin Yuan and Zhongqing Jiang and Wenhui Liu and Yun Tan and Ning Tao",

year = "2011",

language = "English (US)",

volume = "12",

pages = "2597--2600",

journal = "Asian Pacific Journal of Cancer Prevention",

issn = "1513-7368",

publisher = "Asian Pacific Organization for Cancer Prevention",

number = "10",

}

TY - JOUR

T1 - HLA-B*07 is a high risk allele for familial cervical cancer

AU - Qiu, Xiaoping

AU - Zhang, Fan

AU - Chen, Dangxiao

AU - Azad, Abul Kalam

AU - Zhang, Li

AU - Yuan, Yulin

AU - Jiang, Zhongqing

AU - Liu, Wenhui

AU - Tan, Yun

AU - Tao, Ning

PY - 2011

Y1 - 2011

N2 - Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.

AB - Aim: The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group. Methods: Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity. Results: We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1). Conclusions: HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.

KW - Allele

KW - Cervical cancer

KW - Familial risk

KW - HLA

KW - Haplotype

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SN - 1513-7368

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JO - Asian Pacific Journal of Cancer Prevention

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