HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Chloé Loiseau; Daniela Brites; Miriam Reinhard; Kathrin Zürcher; Sonia Borrell; Marie Ballif; Lukas Fenner; Helen Cox; Liliana K. Rutaihwa; Robert J. Wilkinson; Marcel Yotebieng; E. Jane Carter; Alashle Abimiku; Olivier Marcy; Eduardo Gotuzzo; Anchalee Avihingsanon; Nicola Zetola; Basra Doulla; Erik C. Böttger; Matthias Egger; Sebastien Gagneux

doi:10.1128/AAC.00782-20

HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Chloé Loiseau, Daniela Brites, Miriam Reinhard, Kathrin Zürcher, Sonia Borrell, Marie Ballif, Lukas Fenner, Helen Cox, Liliana K. Rutaihwa, Robert J. Wilkinson, Marcel Yotebieng, E. Jane Carter, Alashle Abimiku, Olivier Marcy, Eduardo Gotuzzo, Anchalee Avihingsanon, Nicola Zetola, Basra Doulla, Erik C. Böttger, Matthias EggerSebastien Gagneux

Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

Original language	English (US)
Article number	e00782
Journal	Antimicrobial agents and chemotherapy
Volume	64
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00782-20
State	Published - Oct 2020

Keywords

Drug resistance
Fitness cost
HIV-TB coinfection
Mycobacterium tuberculosis
Rifampicin

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00782-20

Cite this

Loiseau, C., Brites, D., Reinhard, M., Zürcher, K., Borrell, S., Ballif, M., Fenner, L., Cox, H., Rutaihwa, L. K., Wilkinson, R. J., Yotebieng, M., Jane Carter, E., Abimiku, A., Marcy, O., Gotuzzo, E., Avihingsanon, A., Zetola, N., Doulla, B., Böttger, E. C., ... Gagneux, S. (2020). HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 64(10), Article e00782. https://doi.org/10.1128/AAC.00782-20

Loiseau, C, Brites, D, Reinhard, M, Zürcher, K, Borrell, S, Ballif, M, Fenner, L, Cox, H, Rutaihwa, LK, Wilkinson, RJ, Yotebieng, M, Jane Carter, E, Abimiku, A, Marcy, O, Gotuzzo, E, Avihingsanon, A, Zetola, N, Doulla, B, Böttger, EC, Egger, M & Gagneux, S 2020, 'HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis', Antimicrobial agents and chemotherapy, vol. 64, no. 10, e00782. https://doi.org/10.1128/AAC.00782-20

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title = "HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis",

abstract = "We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.",

keywords = "Drug resistance, Fitness cost, HIV-TB coinfection, Mycobacterium tuberculosis, Rifampicin",

author = "Chlo{\'e} Loiseau and Daniela Brites and Miriam Reinhard and Kathrin Z{\"u}rcher and Sonia Borrell and Marie Ballif and Lukas Fenner and Helen Cox and Rutaihwa, {Liliana K.} and Wilkinson, {Robert J.} and Marcel Yotebieng and {Jane Carter}, E. and Alashle Abimiku and Olivier Marcy and Eduardo Gotuzzo and Anchalee Avihingsanon and Nicola Zetola and Basra Doulla and B{\"o}ttger, {Erik C.} and Matthias Egger and Sebastien Gagneux",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 Loiseau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",

year = "2020",

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doi = "10.1128/AAC.00782-20",

language = "English (US)",

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AU - Loiseau, Chloé

AU - Brites, Daniela

AU - Reinhard, Miriam

AU - Zürcher, Kathrin

AU - Borrell, Sonia

AU - Ballif, Marie

AU - Fenner, Lukas

AU - Cox, Helen

AU - Rutaihwa, Liliana K.

AU - Wilkinson, Robert J.

AU - Yotebieng, Marcel

AU - Jane Carter, E.

AU - Abimiku, Alashle

AU - Marcy, Olivier

AU - Gotuzzo, Eduardo

AU - Avihingsanon, Anchalee

AU - Zetola, Nicola

AU - Doulla, Basra

AU - Böttger, Erik C.

AU - Egger, Matthias

AU - Gagneux, Sebastien

PY - 2020/10

Y1 - 2020/10

N2 - We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

AB - We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

KW - Drug resistance

KW - Fitness cost

KW - HIV-TB coinfection

KW - Mycobacterium tuberculosis

KW - Rifampicin

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JO - Antimicrobial agents and chemotherapy

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HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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