HIV-Associated Complications: A Systems-Based Approach

Carolyn Chu, Lealah C. Pollock, Peter A. Selwyn

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Persons with human immunodeficiency virus (HIV) infection often develop complications related directly to the infection, as well as to treatment. Aging, lifestyle factors, and comorbidities increase the risk of developing chronic conditions such as diabetes mellitus and chronic kidney disease. HIV-associated neurologic complications encompass a wide spectrum of pathophysiology and symptomatology. Cardiovascular and pulmonary conditions are common among persons with HIV infection. Although some specific antiretroviral medications have been linked to disease development, traditional risk factors (e.g., smoking) have major roles. Prevention and management of viral hepatitis coinfection are important to reduce morbidity and mortality, and new anti-hepatitis C agents produce high rates of sustained virologic response. Antiretroviral-associated metabolic complications include dyslipidemia, hyperglycemia, and loss of bone mineral density. Newer options generally pose less risk of significant systemic toxicity and are better tolerated. Family physicians who care for patients with HIV infection have a key role in identifying and managing many of these chronic complications.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalAmerican family physician
Issue number3
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • Family Practice


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