Historical perspective of peptidomics

Michael Schrader, Peter Schulz-Knappe, Lloyd D. Fricker

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Peptides have been studied for over 100 years, but for most of this time the focus was on a specific peptide or peptides, and not on the general peptidome of a biological sample. In the 1990s, mass spectrometry techniques were developed for the analysis of proteins, usually after digestion into peptides. The field of peptidomics started soon after proteomics and has grown to over 600 publications that use the word "peptidomic" or "peptidomics". Although peptidomics is related to proteomics, there are fundamental differences. In this review, we discuss these differences along with the history of the field of peptidomics.

Original languageEnglish (US)
Pages (from-to)171-182
Number of pages12
JournalEuPA Open Proteomics
StatePublished - Jun 2014


  • Biomarker discovery
  • Neuropeptides
  • Peptide hormones
  • Peptide research
  • Peptidome
  • Peptidomic

ASJC Scopus subject areas

  • Biochemistry


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