TY - JOUR
T1 - Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock
AU - DiTacchio, Luciano
AU - Le, Hiep D.
AU - Vollmers, Christopher
AU - Hatori, Megumi
AU - Witcher, Michael
AU - Secombe, Julie
AU - Panda, Satchidananda
PY - 2011/9/30
Y1 - 2011/9/30
N2 - In animals, circadian oscillators are based on a transcription-translation circuit that revolves around the transcription factors CLOCK and BMAL1. We found that the JumonjiC (JmjC) and ARID domain - containing histone lysine demethylase 1a (JARID1a) formed a complex with CLOCK-BMAL1, which was recruited to the Per2 promoter. JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner. Depletion of JARID1a in mammalian cells reduced Per promoter histone acetylation, dampened expression of canonical circadian genes, and shortened the period of circadian rhythms. Drosophila lines with reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered circadian rhythms. JARID1a thus has a nonredundant role in circadian oscillator function.
AB - In animals, circadian oscillators are based on a transcription-translation circuit that revolves around the transcription factors CLOCK and BMAL1. We found that the JumonjiC (JmjC) and ARID domain - containing histone lysine demethylase 1a (JARID1a) formed a complex with CLOCK-BMAL1, which was recruited to the Per2 promoter. JARID1a increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1 in a demethylase-independent manner. Depletion of JARID1a in mammalian cells reduced Per promoter histone acetylation, dampened expression of canonical circadian genes, and shortened the period of circadian rhythms. Drosophila lines with reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered circadian rhythms. JARID1a thus has a nonredundant role in circadian oscillator function.
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U2 - 10.1126/science.1206022
DO - 10.1126/science.1206022
M3 - Article
C2 - 21960634
AN - SCOPUS:80053355301
SN - 0036-8075
VL - 333
SP - 1881
EP - 1885
JO - Science
JF - Science
IS - 6051
ER -