@article{33aca25b1fe44f86b1b6e97170e1355a,
title = "High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection",
abstract = "The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends < .01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.",
keywords = "HIV, Oral HPV, Oropharyngeal cancer, Persistence, Viral load",
author = "Beachler, {Daniel C.} and Yingshi Guo and Wiehong Xiao and Burk, {Robert D.} and Howard Minkoff and Strickler, {Howard D.} and Cranston, {Ross D.} and Wiley, {Dorothy J.} and Jacobson, {Lisa P.} and Weber, {Kathleen M.} and Margolick, {Joseph B.} and Sugar, {Elizabeth A.} and Susheel Reddy and Gillison, {Maura L.} and Gypsyamber D'Souza",
note = "Funding Information: Financial support. This work was supported by the National Institute of Dental and Craniofacial Research (R01 DE021395 and related supplement to G. D. [principal investigator]), the National Institute of Allergy and Infectious Disease (U01-A1-35043), and the National Cancer Institute (T32 CA CA009314 and cancer prevention fellowship to D. C. B.). Funding Information: The Multicenter AIDS Cohort Study (MACS) centers in the Persistent Oral Papillomavirus Study (POPS) are funded by U01-AI35042 (Johns Hopkins University-Margolick), U01-AI35039 (Northwestern University-Wolinsky), and U01-AI35041 (University of Pittsburgh-Rinaldo). The MACS DMAC at Johns Hopkins University is funded by UM1-AI35043 (Jacobson). MACS data collection is also supported by UL1-TR000424 (JHU CTSA). The Women's Interagency HIV Study (WIHS) centers in the POPS are funded by U01-AI-031834 (Brooklyn-Minkoff and Gustafson), U01-AI-034993 (Chicago-Cohen), and U01-AI-034993 (Washington-Young). The WIHS DMAC is funded by U01-AI-042590 (Gange and Golub). This work was supported by the National Institute of Dental and Craniofacial Research (R01 DE021395 and related supplement to G. D. [ principal investigator]), the National Institute of Allergy and Infectious Disease (U01-A1-35043), and the National Cancer Institute (T32 CA CA009314 and cancer prevention fellowship to D. C. B.). Funding Information: Acknowledgments. The Multicenter AIDS Cohort Study (MACS) centers in the Persistent Oral Papillomavirus Study (POPS) are funded by U01-AI35042 (Johns Hopkins University–Margolick), U01-AI35039 (Northwestern University–Wolinsky), and U01-AI35041 (University of Pittsburgh–Rinaldo). The MACS DMAC at Johns Hopkins University is funded by UM1-AI35043 (Jacobson). MACS data collection is also supported by UL1-TR000424 (JHU CTSA). The Women{\textquoteright}s Interagency HIV Study (WIHS) centers in the POPS are funded by U01-AI-031834 (Brooklyn–Minkoff and Gustafson), U01-AI-034993 (Chicago–Cohen), and U01-AI-034993 (Washington–Young). The WIHS DMAC is funded by U01-AI-042590 (Gange and Golub). Publisher Copyright: {\textcopyright} The Author 2015.",
year = "2015",
month = nov,
day = "15",
doi = "10.1093/infdis/jiv273",
language = "English (US)",
volume = "212",
pages = "1588--1591",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}
