Hepatocyte growth factor and clinical diabetes in postmenopausal women

Swapnil N. Rajpathak, Sylvia Wassertheil-Smoller, Jill Crandall, Simin Liu, Gloria Y.F. Ho

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


OBJECTIVE - To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS - A cross-sectional analysis among 892 postmenopausal women within the Women's Health Initiative Observational Study (WHI-OS). RESULTS - HGF levels positively correlated with BMI and homeostasis model assessment for insulin resistance. In the multivariable analysis comparing the highest tertile with the lowest tertile of HGF, the odds ratio for prevalent diabetes was 2.47 (95% CI [1.12-5.47], P for trend= 0.014) after accounting for age, race, BMI, and other risk factors for diabetes. CONCLUSIONS - HGF levels are associated with the presence of type 2 diabetes in postmenopausal women. Future studies should consider the prospective evaluation of the association of HGF with the development of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)2013-2015
Number of pages3
JournalDiabetes care
Issue number9
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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