Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

Ilona Argirion; Parag Mahale; Ruth M. Pfeiffer; Ping Liu; Adaora A. Adimora; Matthew J. Akiyama; Hector H. Bolivar; Audrey French; Michael Plankey; Jennifer C. Price; Aadia Rana; Anandi Sheth; Jill Koshiol; Eric C. Seaberg; Mark H. Kuniholm; Jeffrey Glenn; Thomas R. O’Brien

doi:10.3389/fmed.2023.1070420

Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

Ilona Argirion, Parag Mahale, Ruth M. Pfeiffer, Ping Liu, Adaora A. Adimora, Matthew J. Akiyama, Hector H. Bolivar, Audrey French, Michael Plankey, Jennifer C. Price, Aadia Rana, Anandi Sheth, Jill Koshiol, Eric C. Seaberg, Mark H. Kuniholm, Jeffrey Glenn, Thomas R. O’Brien

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.

Original language	English (US)
Article number	1070420
Journal	Frontiers in Medicine
Volume	10
DOIs	https://doi.org/10.3389/fmed.2023.1070420
State	Published - 2023

Keywords

anti-HDV
epidemiology
hepatitis B virus
hepatitis C virus
hepatitis D virus
persons who injected drugs

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fmed.2023.1070420

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Argirion, I., Mahale, P., Pfeiffer, R. M., Liu, P., Adimora, A. A., Akiyama, M. J., Bolivar, H. H., French, A., Plankey, M., Price, J. C., Rana, A., Sheth, A., Koshiol, J., Seaberg, E. C., Kuniholm, M. H., Glenn, J., & O’Brien, T. R. (2023). Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States. Frontiers in Medicine, 10, Article 1070420. https://doi.org/10.3389/fmed.2023.1070420

Argirion, I, Mahale, P, Pfeiffer, RM, Liu, P, Adimora, AA, Akiyama, MJ, Bolivar, HH, French, A, Plankey, M, Price, JC, Rana, A, Sheth, A, Koshiol, J, Seaberg, EC, Kuniholm, MH, Glenn, J & O’Brien, TR 2023, 'Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States', Frontiers in Medicine, vol. 10, 1070420. https://doi.org/10.3389/fmed.2023.1070420

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title = "Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States",

abstract = "Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.",

keywords = "anti-HDV, epidemiology, hepatitis B virus, hepatitis C virus, hepatitis D virus, persons who injected drugs",

author = "Ilona Argirion and Parag Mahale and Pfeiffer, {Ruth M.} and Ping Liu and Adimora, {Adaora A.} and Akiyama, {Matthew J.} and Bolivar, {Hector H.} and Audrey French and Michael Plankey and Price, {Jennifer C.} and Aadia Rana and Anandi Sheth and Jill Koshiol and Seaberg, {Eric C.} and Kuniholm, {Mark H.} and Jeffrey Glenn and O{\textquoteright}Brien, {Thomas R.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Argirion, Mahale, Pfeiffer, Liu, Adimora, Akiyama, Bolivar, French, Plankey, Price, Rana, Sheth, Koshiol, Seaberg, Kuniholm, Glenn and O{\textquoteright}Brien.",

year = "2023",

doi = "10.3389/fmed.2023.1070420",

language = "English (US)",

volume = "10",

journal = "Frontiers in Medicine",

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T1 - Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

AU - Argirion, Ilona

AU - Mahale, Parag

AU - Pfeiffer, Ruth M.

AU - Liu, Ping

AU - Adimora, Adaora A.

AU - Akiyama, Matthew J.

AU - Bolivar, Hector H.

AU - French, Audrey

AU - Plankey, Michael

AU - Price, Jennifer C.

AU - Rana, Aadia

AU - Sheth, Anandi

AU - Koshiol, Jill

AU - Seaberg, Eric C.

AU - Kuniholm, Mark H.

AU - Glenn, Jeffrey

AU - O’Brien, Thomas R.

PY - 2023

Y1 - 2023

N2 - Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.

AB - Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.

KW - anti-HDV

KW - epidemiology

KW - hepatitis B virus

KW - hepatitis C virus

KW - hepatitis D virus

KW - persons who injected drugs

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ER -

Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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