Hepatitis B and End-Stage Liver Disease

Ilan S. Weisberg, Robert S. Brown, Samuel H. Sigal

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Hepatitis B virus (HBV) is the most common cause of chronic hepatitis and end-stage liver disease worldwide. Untreated, chronic hepatitis B acquired early in life results in cirrhosis, liver failure, or hepatocellular carcinoma in up to 40% of individuals. Until recently, the options for a patient who had end-stage hepatitis B cirrhosis were severely limited, but during the past 15 years great strides have been made in prevention and treatment of hepatitis B cirrhosis. This article reviews recent advances in the understanding of the natural history, prevention, and medical management of HBV-related end-stage liver disease.

Original languageEnglish (US)
Pages (from-to)893-916
Number of pages24
JournalClinics in Liver Disease
Issue number4
StatePublished - Nov 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology


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