Hemoglobin miyada: DNA analysis of the anti‐lepore βδ fusion gene

M. Catherine Driscoll, Yoshiro Ohta, Frank Nakamura, Arthur Bloom, Arthur Bank

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Hemoglobin Miyada, an anti‐Lepore hemoglobin, represents the protein product of a nonhomologous crossover between β and δ genes. The mutant globin is β‐like from the N terminus to amino acid 12, and δ‐like from amino acid 22 through the C terminus, thus predicting a crossover site in the first coding region of the gene. DNA analysis, using multiple restriction endonucleases and hybridization to δ and β globin gene‐specific probes, confirms that the βδ hybrid gene 1) is located on a single chromosomal fragment between normal δ and β genes, and 2) has 5′ β promoter sequences, δ IVS 1 and 2, and 3′ coding and flanking sequences.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalAmerican Journal of Hematology
Issue number4
StatePublished - Dec 1984
Externally publishedYes


  • gene analysis
  • hemoglobin Miyada

ASJC Scopus subject areas

  • Hematology


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