Hematopoietic Stem Cell Metabolism during Development and Aging

Ayako Nakamura-Ishizu; Keisuke Ito; Toshio Suda

doi:10.1016/j.devcel.2020.06.029

Hematopoietic Stem Cell Metabolism during Development and Aging

Ayako Nakamura-Ishizu, Keisuke Ito, Toshio Suda

Cell Biology

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.

Original language	English (US)
Pages (from-to)	239-255
Number of pages	17
Journal	Developmental cell
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2020.06.029
State	Published - Jul 20 2020

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2020.06.029

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title = "Hematopoietic Stem Cell Metabolism during Development and Aging",

abstract = "Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.",

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AU - Nakamura-Ishizu, Ayako

AU - Ito, Keisuke

AU - Suda, Toshio

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Y1 - 2020/7/20

N2 - Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.

AB - Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.

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JO - Developmental cell

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Hematopoietic Stem Cell Metabolism during Development and Aging

Abstract

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