Hedgehog signaling and radiation induced liver injury: A delicate balance

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalHepatology International
Issue number3
StatePublished - Jul 2014


  • Hedgehog signaling
  • Radiation-induced liver disease

ASJC Scopus subject areas

  • Hepatology


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