TY - JOUR
T1 - Hedgehog signaling and radiation induced liver injury
T2 - A delicate balance
AU - Kabarriti, Rafi
AU - Guha, Chandan
PY - 2014/7
Y1 - 2014/7
N2 - Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.
AB - Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.
KW - Hedgehog signaling
KW - Radiation-induced liver disease
UR - http://www.scopus.com/inward/record.url?scp=84905564017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905564017&partnerID=8YFLogxK
U2 - 10.1007/s12072-014-9532-x
DO - 10.1007/s12072-014-9532-x
M3 - Review article
AN - SCOPUS:84905564017
SN - 1936-0533
VL - 8
SP - 316
EP - 320
JO - Hepatology International
JF - Hepatology International
IS - 3
ER -
