Heart failure in diabetes

Stanislovas S. Jankauskas; Urna Kansakar; Fahimeh Varzideh; Scott Wilson; Pasquale Mone; Angela Lombardi; Jessica Gambardella; Gaetano Santulli

doi:10.1016/j.metabol.2021.154910

Heart failure in diabetes

Stanislovas S. Jankauskas, Urna Kansakar, Fahimeh Varzideh, Scott Wilson, Pasquale Mone, Angela Lombardi, Jessica Gambardella, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.

Original language	English (US)
Article number	154910
Journal	Metabolism: Clinical and Experimental
Volume	125
DOIs	https://doi.org/10.1016/j.metabol.2021.154910
State	Published - Dec 2021

Keywords

Adrenergic receptors
Aging
BHB
Bioenergetics
Cardiomyocytes
Cardiovascular endocrinology
Diabetes mellitus
Diabetic cardiomyopathy
Diastolic dysfunction
Endothelium
FOXO1
Fibroblasts
Fibrosis
HFpEF
Heart failure
Mitochondria
NADH
Oxidative stress
ROS
Senescence
T1DM
T2DM
VSMC

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.metabol.2021.154910

Cite this

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title = "Heart failure in diabetes",

abstract = "Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.",

keywords = "Adrenergic receptors, Aging, BHB, Bioenergetics, Cardiomyocytes, Cardiovascular endocrinology, Diabetes mellitus, Diabetic cardiomyopathy, Diastolic dysfunction, Endothelium, FOXO1, Fibroblasts, Fibrosis, HFpEF, Heart failure, Mitochondria, NADH, Oxidative stress, ROS, Senescence, T1DM, T2DM, VSMC",

author = "Jankauskas, {Stanislovas S.} and Urna Kansakar and Fahimeh Varzideh and Scott Wilson and Pasquale Mone and Angela Lombardi and Jessica Gambardella and Gaetano Santulli",

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year = "2021",

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doi = "10.1016/j.metabol.2021.154910",

language = "English (US)",

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AU - Jankauskas, Stanislovas S.

AU - Kansakar, Urna

AU - Varzideh, Fahimeh

AU - Wilson, Scott

AU - Mone, Pasquale

AU - Lombardi, Angela

AU - Gambardella, Jessica

AU - Santulli, Gaetano

PY - 2021/12

Y1 - 2021/12

N2 - Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.

AB - Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.

KW - Adrenergic receptors

KW - Aging

KW - BHB

KW - Bioenergetics

KW - Cardiomyocytes

KW - Cardiovascular endocrinology

KW - Diabetes mellitus

KW - Diabetic cardiomyopathy

KW - Diastolic dysfunction

KW - Endothelium

KW - FOXO1

KW - Fibroblasts

KW - Fibrosis

KW - HFpEF

KW - Heart failure

KW - Mitochondria

KW - NADH

KW - Oxidative stress

KW - ROS

KW - Senescence

KW - T1DM

KW - T2DM

KW - VSMC

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DO - 10.1016/j.metabol.2021.154910

M3 - Review article

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JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

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ER -

Heart failure in diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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