TY - JOUR
T1 - Health-related quality of life in tension-type headache
T2 - A population-based study
AU - Ashina, Sait
AU - Buse, Dawn C.
AU - Bjorner, Jakob B.
AU - Bendtsen, Lars
AU - Lyngberg, Ann C.
AU - Jensen, Rigmor H.
AU - Lipton, Richard B.
N1 - Funding Information:
Research funding: The study was supported by the East Denmark Health Science Research Forum, the Danish Medical Association Research Fund, the Danish Health Insurance Foundation, the Danish Hospital Foundation for Medical Research, the Danish Headache Society, the Cool Sorption Foundation, GlaxoSmithKline A/S, Merck Sharp Dohme A/S, Pfizer A/S, Lundbeck Pharma A/S and H. Lundbeck A/S. The funding sources have not been involved in the conduct of the study.
Funding Information:
Competing interests: Sait Ashina, MD received honoraria for consulting from Allergan, Amgen, Eli Lilly, Impel NeuroPharma, Percept, Novartis, Satsuma, Supernus, Theranica. Dawn C Buse, PhD has received grant support and honoraria from Allergan, Amgen, Biohaven, Lilly, Novartis, and Promus/Dr. Reddys. She has not been paid by any company for work writing manuscripts, or writing or presenting abstracts, posters or platforms. She serves on the editorial boards of Current Pain and Headache Reports, the Journal of Headache and Pain, Pain Medicine News, and Pain Pathways magazine. Jakob B. Bjorner works for QualityMetric, who licenses the SF-12 Health Survey. Lars Bendtsen, MD has received honoraria for lectures from MSD, Allergan and Pfizer and serves on the scientific advisory board for Berlin-Chemie. Ann C Lyngberg, MD has no disclosures. Rigmor H. Jensen, MD has received honoraria for lectures and patient leaflets from MSD, Berlin-Chemie Menarini, ATI, Novartis, Teva, Allergan and Pfizer and is conducting clinical trials for Eli-Lilly and Lundbeck. Richard B Lipton, MD receives research support from the NIH, the FDA, the S and L Marx Foundation, the Migraine Research Foundation, and the National Headache Foundation. He holds stock options in Biohaven Holdings and CtrlM Health. He serves as consultant, advisory board member, has received honoraria from or research support from: Abbvie (Allergan), American Academy of Neurology, American Headache Society, Amgen, Biohaven, Biovision, Boston Scientific, Dr. Reddy’s (Promius), Electrocore, Eli Lilly, eNeura, Equinox, GlaxoSmithKline, Grifols, Lundbeck (Alder), Merck, Pernix, Pfizer, Teva, Vector and Vedanta. ®
Publisher Copyright:
© 2020 Sait Ashina et al., published by De Gruyter, Berlin/Boston.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Objectives: Tension-type headache (TTH) is the most prevalent primary headache disorder. We assessed the cross-sectional impact of TTH on health related quality of life (HRQoL) in a general population. We also examined the association of HRQoL scores with headache frequency, disability, medication overuse, poor self-rated health, psychiatric comorbidity, and pain sensitivity in individuals with TTH. Methods: A sample of 547 subjects completed a headache diagnostic interview, the SF-12 to calculate physical (PCS) and mental (MCS) health component scores, depression (major depression inventory [MDI]) and neuroticism (Eysenck Personality Questionnaire) measures. We defined the following headache diagnosis categories: pure TTH, pure migraine, and coexistent headache (TTH + migraine). Cases were further classified into chronic (≥15) or episodic (<15 headache days/month). Results: Using generalized linear models (GLM) adjusted for age, sex and education, both PCS-12 and MCS-12 scores varied in groups distinguished by migraine and TTH status; scores were lower for individuals with coexistent headache (TTH + migraine; n=83), followed by pure TTH (n=97) and pure migraine (n=43) compared to the no headache group (n=324) (p≤0.001). In analyses considering chronicity, PCS-12 scores were lower in chronic coexistent headache followed by pure chronic TTH (CTTH), episodic migraine +/- episodic TTH (ETTH) and pure ETTH than in the no headache group (p≤0.001). MCS-12 scores were lower in pure CTTH, followed by chronic coexistent headache, episodic migraine +/- ETTH and pure ETTH compared to the no headache group (p≤0.001). Multiple regression models showed that in TTH, lower PCS-12 scores were associated with age (p=0.04), female sex (p=0.02), and poor self-rated health (p≤0.001). Lower MCS-12 scores in TTH were associated with depression (p≤0.001). Conclusions: In a population sample, TTH, and to higher degree CTTH, are associated with decreased HRQoL.
AB - Objectives: Tension-type headache (TTH) is the most prevalent primary headache disorder. We assessed the cross-sectional impact of TTH on health related quality of life (HRQoL) in a general population. We also examined the association of HRQoL scores with headache frequency, disability, medication overuse, poor self-rated health, psychiatric comorbidity, and pain sensitivity in individuals with TTH. Methods: A sample of 547 subjects completed a headache diagnostic interview, the SF-12 to calculate physical (PCS) and mental (MCS) health component scores, depression (major depression inventory [MDI]) and neuroticism (Eysenck Personality Questionnaire) measures. We defined the following headache diagnosis categories: pure TTH, pure migraine, and coexistent headache (TTH + migraine). Cases were further classified into chronic (≥15) or episodic (<15 headache days/month). Results: Using generalized linear models (GLM) adjusted for age, sex and education, both PCS-12 and MCS-12 scores varied in groups distinguished by migraine and TTH status; scores were lower for individuals with coexistent headache (TTH + migraine; n=83), followed by pure TTH (n=97) and pure migraine (n=43) compared to the no headache group (n=324) (p≤0.001). In analyses considering chronicity, PCS-12 scores were lower in chronic coexistent headache followed by pure chronic TTH (CTTH), episodic migraine +/- episodic TTH (ETTH) and pure ETTH than in the no headache group (p≤0.001). MCS-12 scores were lower in pure CTTH, followed by chronic coexistent headache, episodic migraine +/- ETTH and pure ETTH compared to the no headache group (p≤0.001). Multiple regression models showed that in TTH, lower PCS-12 scores were associated with age (p=0.04), female sex (p=0.02), and poor self-rated health (p≤0.001). Lower MCS-12 scores in TTH were associated with depression (p≤0.001). Conclusions: In a population sample, TTH, and to higher degree CTTH, are associated with decreased HRQoL.
KW - depression
KW - migraine
KW - pain sensitivity
KW - quality of life
KW - tension-type headache
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U2 - 10.1515/sjpain-2020-0166
DO - 10.1515/sjpain-2020-0166
M3 - Article
C2 - 33544560
AN - SCOPUS:85099959831
SN - 1877-8860
VL - 21
SP - 778
EP - 787
JO - Scandinavian Journal of Pain
JF - Scandinavian Journal of Pain
IS - 4
ER -