@article{97c24fd97c6d42689ede2e1416e8b6bb,
title = "Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus",
abstract = "We report the synthesis and evaluation of 5-halogenated-1,2,3-Triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-Triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 μg/mL.",
keywords = "antibiotic, biotin protein ligase, enzyme inhibitor, Staphylococcus aureus",
author = "Paparella, {Ashleigh S.} and Lee, {Kwang Jun} and Hayes, {Andrew J.} and Jiage Feng and Zikai Feng and Danielle Cini and Sonali Deshmukh and Booker, {Grant W.} and Wilce, {Matthew C.J.} and Polyak, {Steven W.} and Abell, {Andrew D.}",
note = "Funding Information: This work was supported by the National Health and Medical Research Council of Australia (application APP1068885). We are grateful to the Wallace and Carthew families for their financial support of this work. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2018",
month = feb,
day = "9",
doi = "10.1021/acsinfecdis.7b00134",
language = "English (US)",
volume = "4",
pages = "175--184",
journal = "ACS Infectious Diseases",
issn = "2373-8227",
publisher = "American Chemical Society",
number = "2",
}
