Haemophilus influenzae

W. A. Szymczak; Michael H. Levi; J. W. Johnston; M. A. Apicella

doi:10.1016/B978-0-12-801238-3.02294-7

Haemophilus influenzae

W. A. Szymczak, Michael H. Levi, J. W. Johnston, M. A. Apicella

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Haemophilus influenzae is a Gram-negative, strict human pathogen that can colonize hosts in an asymptomatic manner or can cause invasive disease. To persist in the host, the organism utilizes many virulence factors that are regulated in a complex manner. Virulence factors include the polysaccharide capsule of encapsulated strains, lipooligosaccharide extending from the cell membrane, and many proteins involved in adhesion of the bacterium to respiratory epithelial cells. In this review, we describe the major mechanisms of virulence and how they contribute to colonization and invasive disease.

Original language	English (US)
Title of host publication	Encyclopedia of Microbiology
Publisher	Elsevier
Pages	481-494
Number of pages	14
ISBN (Electronic)	9780128117378
ISBN (Print)	9780128117361
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.02294-7
State	Published - Jan 1 2019

Keywords

Biofilm
Capsule
Chronic obstructive pulmonary disease
Colonization
Haemophilus
Lipooligosaccharide
Meningitis
Otitis media
Pathogenesis
Phase variation
Pneumonia
Sepsis
Vaccine
Virulence

ASJC Scopus subject areas

Immunology and Microbiology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-801238-3.02294-7

Cite this

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title = "Haemophilus influenzae",

abstract = "Haemophilus influenzae is a Gram-negative, strict human pathogen that can colonize hosts in an asymptomatic manner or can cause invasive disease. To persist in the host, the organism utilizes many virulence factors that are regulated in a complex manner. Virulence factors include the polysaccharide capsule of encapsulated strains, lipooligosaccharide extending from the cell membrane, and many proteins involved in adhesion of the bacterium to respiratory epithelial cells. In this review, we describe the major mechanisms of virulence and how they contribute to colonization and invasive disease.",

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doi = "10.1016/B978-0-12-801238-3.02294-7",

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T1 - Haemophilus influenzae

AU - Szymczak, W. A.

AU - Levi, Michael H.

AU - Johnston, J. W.

AU - Apicella, M. A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Haemophilus influenzae is a Gram-negative, strict human pathogen that can colonize hosts in an asymptomatic manner or can cause invasive disease. To persist in the host, the organism utilizes many virulence factors that are regulated in a complex manner. Virulence factors include the polysaccharide capsule of encapsulated strains, lipooligosaccharide extending from the cell membrane, and many proteins involved in adhesion of the bacterium to respiratory epithelial cells. In this review, we describe the major mechanisms of virulence and how they contribute to colonization and invasive disease.

AB - Haemophilus influenzae is a Gram-negative, strict human pathogen that can colonize hosts in an asymptomatic manner or can cause invasive disease. To persist in the host, the organism utilizes many virulence factors that are regulated in a complex manner. Virulence factors include the polysaccharide capsule of encapsulated strains, lipooligosaccharide extending from the cell membrane, and many proteins involved in adhesion of the bacterium to respiratory epithelial cells. In this review, we describe the major mechanisms of virulence and how they contribute to colonization and invasive disease.

KW - Biofilm

KW - Capsule

KW - Chronic obstructive pulmonary disease

KW - Colonization

KW - Haemophilus

KW - Lipooligosaccharide

KW - Meningitis

KW - Otitis media

KW - Pathogenesis

KW - Phase variation

KW - Pneumonia

KW - Sepsis

KW - Vaccine

KW - Virulence

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U2 - 10.1016/B978-0-12-801238-3.02294-7

DO - 10.1016/B978-0-12-801238-3.02294-7

M3 - Chapter

AN - SCOPUS:85079529950

SN - 9780128117361

SP - 481

EP - 494

BT - Encyclopedia of Microbiology

PB - Elsevier

ER -

Haemophilus influenzae

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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