TY - JOUR
T1 - H1° histone and differentiation of dendritic cells. A molecular target for tumor-derived factors
AU - Gabrilovich, Dmitry I.
AU - Cheng, Pingyan
AU - Fan, Yuhong
AU - Yu, Bin
AU - Nikitina, Ekaterina
AU - Sirotkin, Allen
AU - Shurin, Michael
AU - Oyama, Tsunehiro
AU - Adachi, Yasushi
AU - Nadaf, Sorena
AU - Carbone, David P.
AU - Skoultchi, Arthur I.
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Dendritic cells (DC) play a central role in antitumor immune responses. Abnormal differentiation of DC and their inability to stimulate T cells are important factors in tumor escape from immune-system control. However, the mechanisms of this process remain elusive. Here, we have described one possible molecular mechanism that involves replacement linker histone H1°. A close association between expression of H1° and DC differentiation in vitro has been found. DC production in H1°-deficient mice was decreased significantly, whereas generation and function of macrophages, granulocytes, and lymphocytes appear to be normal. However, these mice had a significantly reduced response to vaccination with antigens. Tumor-derived factors considerably reduced h1° expression in hematopoietic progenitor cells. We have demonstrated that transcription factor NF-κB is involved actively in regulation of h1°. Thus, H1° histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1° expression.
AB - Dendritic cells (DC) play a central role in antitumor immune responses. Abnormal differentiation of DC and their inability to stimulate T cells are important factors in tumor escape from immune-system control. However, the mechanisms of this process remain elusive. Here, we have described one possible molecular mechanism that involves replacement linker histone H1°. A close association between expression of H1° and DC differentiation in vitro has been found. DC production in H1°-deficient mice was decreased significantly, whereas generation and function of macrophages, granulocytes, and lymphocytes appear to be normal. However, these mice had a significantly reduced response to vaccination with antigens. Tumor-derived factors considerably reduced h1° expression in hematopoietic progenitor cells. We have demonstrated that transcription factor NF-κB is involved actively in regulation of h1°. Thus, H1° histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1° expression.
KW - Cellular differentiation
KW - Monocytes/macrophages
KW - Tumor immunity
UR - http://www.scopus.com/inward/record.url?scp=0036667326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036667326&partnerID=8YFLogxK
M3 - Article
C2 - 12149419
AN - SCOPUS:0036667326
SN - 0741-5400
VL - 72
SP - 285
EP - 296
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 2
ER -