TY - JOUR
T1 - Gunn Rat
T2 - A Model for Inherited Deficiency of Bilirubin Glucuronidation
AU - Chowdhury, Jayanta Roy
AU - Kondapalli, R. A.V.I.
AU - Chowdhury, Namita Roy
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Experiments in Gunn rats have provided important insights into physiological, biochemical, and molecular mechanisms of bilirubin conjugation and disposition. The Gunn rat is a natural model for bilirubin encephalopathy, and much of our knowledge of bilirubin toxicity and its treatment has come from studies performed in Gunn rats. The genetic lesion in Gunn rats closely parallel those in Crigler-Najjar syndrome, Type I. Presently, the Gunn rat model is being used to develop methods for gene therapy for inherited bilirubin-UGT deficiency. Thus, Gunn rats continue to be a valuable model for the investigation of inherited UGT deficiency and severe nonhemolytic unconjugated hyperbilirubinemia.
AB - Experiments in Gunn rats have provided important insights into physiological, biochemical, and molecular mechanisms of bilirubin conjugation and disposition. The Gunn rat is a natural model for bilirubin encephalopathy, and much of our knowledge of bilirubin toxicity and its treatment has come from studies performed in Gunn rats. The genetic lesion in Gunn rats closely parallel those in Crigler-Najjar syndrome, Type I. Presently, the Gunn rat model is being used to develop methods for gene therapy for inherited bilirubin-UGT deficiency. Thus, Gunn rats continue to be a valuable model for the investigation of inherited UGT deficiency and severe nonhemolytic unconjugated hyperbilirubinemia.
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U2 - 10.1016/B978-0-12-039237-7.50013-3
DO - 10.1016/B978-0-12-039237-7.50013-3
M3 - Article
C2 - 8273513
AN - SCOPUS:0027766088
SN - 0065-3519
VL - 37
SP - 149
EP - 173
JO - Advances in Veterinary Science and Comparative Medicine
JF - Advances in Veterinary Science and Comparative Medicine
IS - C
ER -