Guide RNA acrobatics: The one-for-two shuffle

U. Thomas Meier

doi:10.1101/gad.349285.121

Guide RNA acrobatics: The one-for-two shuffle

U. Thomas Meier

Cell Biology

Research output: Contribution to journal › Article › peer-review

Abstract

RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Genes and Development
Volume	36
Issue number	1-5
DOIs	https://doi.org/10.1101/gad.349285.121
State	Published - 2022

Keywords

RNA-RNA interaction
RNA-guided RNA modification
box H/ACA RNAs
guide RNA acrobatics
pseudouridine
pseudouridylation

ASJC Scopus subject areas

General Medicine

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10.1101/gad.349285.121

Cite this

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Guide RNA acrobatics: The one-for-two shuffle

Abstract

Keywords

ASJC Scopus subject areas

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