Guide RNA acrobatics: The one-for-two shuffle

Research output: Contribution to journalArticlepeer-review


RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jády and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalGenes and Development
Issue number1-5
StatePublished - 2022


  • RNA-RNA interaction
  • RNA-guided RNA modification
  • box H/ACA RNAs
  • guide RNA acrobatics
  • pseudouridine
  • pseudouridylation

ASJC Scopus subject areas

  • General Medicine


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