TY - JOUR
T1 - Gray matter volume covariance networks associated with social networks in older adults
AU - Blumen, Helena M.
AU - Verghese, Joe
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/9/3
Y1 - 2019/9/3
N2 - Extensive social networks are associated with better physical, mental, and cognitive health in aging, but the underlying brain substrates remain largely unexplored. Voxel-based morphometry and multivariate statistics were used to identify gray matter volume covariance networks associated with social networks in 86 older adults without dementia (M Age = 75.20 years, 53% women). Gray matter networks associated with the number of high-contact social roles and the total number of network members were identified after adjusting for age, sex, education, global health, and total intracranial volume–and shared nodes included medial, lateral and orbital prefrontal, hippocampal, precuneus, insular, and cingulate regions. Greater expression of these gray matter networks was associated with better memory scores on the Free and Cued Selective Reminding Test. A more distributed network was associated with high-contact social roles than total number of networks members–also extending into amygdala and entorhinal cortex. Thus, high-contact social roles and total number of network members in older adults are associated with gray matter networks composed of regions previously linked to memory and affected by both healthy aging and Alzheimer disease–and high-contact social roles are more strongly associated with brain structures than the total number of network members.
AB - Extensive social networks are associated with better physical, mental, and cognitive health in aging, but the underlying brain substrates remain largely unexplored. Voxel-based morphometry and multivariate statistics were used to identify gray matter volume covariance networks associated with social networks in 86 older adults without dementia (M Age = 75.20 years, 53% women). Gray matter networks associated with the number of high-contact social roles and the total number of network members were identified after adjusting for age, sex, education, global health, and total intracranial volume–and shared nodes included medial, lateral and orbital prefrontal, hippocampal, precuneus, insular, and cingulate regions. Greater expression of these gray matter networks was associated with better memory scores on the Free and Cued Selective Reminding Test. A more distributed network was associated with high-contact social roles than total number of networks members–also extending into amygdala and entorhinal cortex. Thus, high-contact social roles and total number of network members in older adults are associated with gray matter networks composed of regions previously linked to memory and affected by both healthy aging and Alzheimer disease–and high-contact social roles are more strongly associated with brain structures than the total number of network members.
KW - Social networks
KW - aging
KW - multivariate statistics
KW - neuroimaging
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U2 - 10.1080/17470919.2018.1535999
DO - 10.1080/17470919.2018.1535999
M3 - Article
C2 - 30324863
AN - SCOPUS:85055502741
SN - 1747-0919
VL - 14
SP - 559
EP - 570
JO - Social Neuroscience
JF - Social Neuroscience
IS - 5
ER -