Glucose clearance is delayed after hyperglycemia in healthy elderly men

Raj K. Krishnan, William J. Evans, John P. Kirwant

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Delayed glucose clearance after hyperglycemia may contribute to insulin resistance. Rates of glucose and insulin decay were measured after 3 h of sustained hyperglycemia (10 mmol/L) in 8 healthy older men (66 ± 2y) and were compared with those of 8 younger men (22 ± 1y). Fractional glucose clearance rates were calculated by regression analysis. Insulin decay was estimated from insulin levels through 30 min postinfusion. Abdominal adiposity was estimated from waist-to-hip ratios. Body weight and basal plasma glucose, insulin and C-peptide concentrations did not differ between groups. Fat mass, abdominal adiposity, fasting serum triglycerides and total cholesterol, although normal, were higher (P < 0.05) in the older group. The elderly group experienced lower glucose clearance rates (1.9 ± 0.2 vs. 2.9 ± 0.1%/min, P < 0.002) and higher plasma insulin after hyperglycemia (P < 0.03). Glucose and insulin decay correlated with glucose infusion rates (r = 0.88, P < 0.0002 and r = 0.51, P < 0.05). Delayed glucose clearance was associated with greater abdominal adiposity (r = -0.56, P < 0.03), higher serum triglycerides (r = -0.73, P < 0.003) and elevated serum cholesterol (r = -0.56, P < 0.04). In conclusion, modest increases in abdominal adiposity and circulating lipids are associated with abnormal glucose clearance in clinically healthy older men; this may be a precursor to the development of insulin resistance and related complications that arise from prolonged postprandial hyperglycemia.

Original languageEnglish (US)
Pages (from-to)2363-2366
Number of pages4
JournalJournal of Nutrition
Issue number7
StatePublished - Jul 1 2003
Externally publishedYes


  • Aging
  • Diabetes
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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