TY - JOUR
T1 - Glucosamine use and risk of colorectal cancer
T2 - results from the Cancer Prevention Study II Nutrition Cohort
AU - Kantor, Elizabeth D.
AU - Newton, Christina C.
AU - Giovannucci, Edward L.
AU - McCullough, Marjorie L.
AU - Campbell, Peter T.
AU - Jacobs, Eric J.
N1 - Funding Information:
Acknowledgments The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study II (CPS-II) cohort. We thank the CPS-II participants and Study Management Group for their invaluable contributions to this research. We also acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention’s National Program of Cancer Registries, as well as cancer registries supported by the National Cancer Institute’s Surveillance Epidemiology and End Results program. Elizabeth D. Kantor is supported by the National Cancer Institute of the National Institutes of Health (P30 CA008748).
Funding Information:
The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study II (CPS-II) cohort. We thank the CPS-II participants and Study Management Group for their invaluable contributions to this research. We also acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention’s National Program of Cancer Registries, as well as cancer registries supported by the National Cancer Institute’s Surveillance Epidemiology and End Results program. Elizabeth D. Kantor is supported by the National Cancer Institute of the National Institutes of Health (P30 CA008748).
Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: Use of glucosamine supplements has been associated with reduced risk of colorectal cancer (CRC) in previous studies; however, information on this association remains limited. Methods: We examined the association between glucosamine use and CRC risk among 113,067 men and women in the Cancer Prevention Study II Nutrition Cohort. Glucosamine use was first reported in 2001 and updated every 2 years thereafter. Participants were followed from 2001 through June of 2011, during which time 1440 cases of CRC occurred. Results: As has been observed in prior studies, current use of glucosamine, modeled using a time-varying exposure, was associated with lower risk of CRC (HR 0.83; 95% CI 0.71–0.97) compared to never use. However, for reasons that are unclear, this reduction in risk was observed for shorter-duration use (HR 0.68; 95% CI 0.52–0.87 for current users with ≤ 2 years use) rather than longer-duration use (HR 0.90; 95% CI 0.72–1.13 for current users with 3 to OpenSPiltSPi 6 years of use; HR 0.99; 95% CI 0.76–1.29 for current users with ≥ 6 years of use). Conclusions: Further research is needed to better understand the association between glucosamine use and risk of CRC, and how this association may vary by duration of use.
AB - Purpose: Use of glucosamine supplements has been associated with reduced risk of colorectal cancer (CRC) in previous studies; however, information on this association remains limited. Methods: We examined the association between glucosamine use and CRC risk among 113,067 men and women in the Cancer Prevention Study II Nutrition Cohort. Glucosamine use was first reported in 2001 and updated every 2 years thereafter. Participants were followed from 2001 through June of 2011, during which time 1440 cases of CRC occurred. Results: As has been observed in prior studies, current use of glucosamine, modeled using a time-varying exposure, was associated with lower risk of CRC (HR 0.83; 95% CI 0.71–0.97) compared to never use. However, for reasons that are unclear, this reduction in risk was observed for shorter-duration use (HR 0.68; 95% CI 0.52–0.87 for current users with ≤ 2 years use) rather than longer-duration use (HR 0.90; 95% CI 0.72–1.13 for current users with 3 to OpenSPiltSPi 6 years of use; HR 0.99; 95% CI 0.76–1.29 for current users with ≥ 6 years of use). Conclusions: Further research is needed to better understand the association between glucosamine use and risk of CRC, and how this association may vary by duration of use.
KW - Chemoprevention
KW - Colorectal cancer
KW - Dietary supplements
KW - Epidemiology
KW - Glucosamine
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U2 - 10.1007/s10552-018-1003-6
DO - 10.1007/s10552-018-1003-6
M3 - Article
C2 - 29411204
AN - SCOPUS:85041581496
SN - 0957-5243
VL - 29
SP - 389
EP - 397
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 3
ER -
