Global cognitive function correlates with P-wave dispersion in frail hypertensive older adults

Pasquale Mone, Antonella Pansini, Francesco Calabrò, Stefano De Gennaro, Mafalda Esposito, Paolo Rinaldi, Antonio Colin, Fabio Minicucci, Antonio Coppola, Salvatore Frullone, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


P-Wave Dispersion (PWD) is an ECG parameter defined as the difference between the longest and the shortest P-Wave duration. PWD has been associated with hypertension, a leading cause of age-related cognitive decline. Moreover, hypertension is associated with vascular dementia and Alzheimer's Disease. Based on these considerations, we evaluated PWD and global cognitive function in frail hypertensive older adults with a previous diagnosis of cognitive decline. We evaluated consecutive frail hypertensive patients ≥65-year-old with a Mini-Mental State Examination (MMSE) score <26. Patients with evidence of secondary hypertension, history of stroke, myocardial infarction, or therapy with beta-blockers or acetylcholinesterase inhibitors were excluded. Beta-blocker therapy causes a significant decrease in PWD; patients treated with acetylcholinesterase inhibitors were not included to avoid confounding effects on cognitive function. By examining 180 patients, we found that PWD significantly correlated with MMSE score. Strikingly, these effects were confirmed in a linear multivariate analysis with a regression model. To our knowledge, this is the first study showing that PWD correlates with global cognitive function in frail hypertensive older adults.

Original languageEnglish (US)
Pages (from-to)638-643
Number of pages6
JournalJournal of Clinical Hypertension
Issue number5
StatePublished - May 2022


  • ECG
  • cognitive function
  • frailty
  • hypertension
  • older adults

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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