Global burden of influenza as a cause of cardiopulmonary morbidity and mortality

William A. Fischer, Michelle Gong, Satish Bhagwanjee, Jonathan Sevransky

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Severe acute respiratory infections, including influenza, are a leading cause of cardiopulmonary morbidity and mortality worldwide. Until recently, the epidemiology of influenza was limited to resource-rich countries. Emerging epidemiological reports characterizing the 2009 H1N1 pandemic, however, suggest that influenza exerts an even greater toll in low-income, resource-constrained environments where it is the cause of 5% to 27% of all severe acute respiratory infections. The increased burden of disease in this setting is multifactorial and likely is the result of higher rates of comorbidities such as human immunodeficiency virus, decreased access to health care, including vaccinations and antiviral medications, and limited healthcare infrastructure, including oxygen therapy or critical care support. Improved global epidemiology of influenza is desperately needed to guide allocation of life-saving resources, including vaccines, antiviral medications, and direct the improvement of basic health care tomitigate the impact of influenza infection on the most vulnerable populations.

Original languageEnglish (US)
Pages (from-to)325-336
Number of pages12
JournalGlobal Heart
Issue number3
StatePublished - 2014

ASJC Scopus subject areas

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine


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