TY - JOUR
T1 - Glia and methylmercury neurotoxicity
AU - Ni, Mingwei
AU - Li, Xin
AU - Rocha, João B.T.
AU - Farina, Marcelo
AU - Aschner, Michael
N1 - Funding Information:
We are grateful for support by NIEHS R01ES07331 and the Center in Molecular Toxicology NIH grant P30ES00267. Address correspondence to Michael Aschner, PhD, Vanderbilt University Medical Center, Division of Pediatric Toxicology, 11425 MRB IV 2215-B Garland Ave., Nashville, TN 37232-0414, USA. E-mail: michael.aschner@vanderbilt.edu
PY - 2012/8/15
Y1 - 2012/8/15
N2 - Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.
AB - Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.
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U2 - 10.1080/15287394.2012.697840
DO - 10.1080/15287394.2012.697840
M3 - Article
AN - SCOPUS:84984576536
SN - 1528-7394
VL - 75
SP - 1091
EP - 1101
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 16-17
ER -
