Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations

Paul K.S. Chan, Chuqing Zhang, Jong Sup Park, Karen K. Smith-McCune, Joel M. Palefsky, Lucia Giovannelli, Francois Coutlée, Samantha Hibbitts, Ryo Konno, Wannapa Settheetham-Ishida, Tang Yuan Chu, Annabelle Ferrera, María Alejandra Picconi, Federico De Marco, Yin Ling Woo, Tainá Raiol, Patricia Piña-Sánchez, Jeong Hoon Bae, Martin C.S. Wong, Mike Z. ChirenjeTsitsi Magure, Anna Barbara Moscicki, Alison N. Fiander, Giuseppina Capra, Eun Young Ki, Yi Tan, Zigui Chen, Robert D. Burk, Martin C.W. Chan, Tak Hong Cheung, David Pim, Lawrence Banks

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical distribution and risk association of nucleotide sequence variations were analyzed. We found that the E6 genes of HPV58 variants were more conserved than E7. Thus, E6 is a more appropriate target for type-specific detection, whereas E7 is more appropriate for strain differentiation. The frequency of sequence variation varied geographically. Africa had significantly more isolates with E6-367A (D86E) but significantly less isolates with E6-203G, -245G, -367C (prototype-like) than other regions (p ≤ 0.003). E7-632T, -760A (T20I, G63S) was more frequently found in Asia, and E7-793G (T74A) was more frequent in Africa (p < 0.001). Variants with T20I and G63S substitutions at E7 conferred a significantly higher risk for cervical intraepithelial neoplasia grade III and invasive cervical cancer compared to other HPV58 variants (odds ratio = 4.44, p = 0.007). In conclusion, T20I and/or G63S substitution(s) at E7 of HPV58 is/are associated with a higher risk for cervical neoplasia. These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas.

Original languageEnglish (US)
Pages (from-to)2528-2536
Number of pages9
JournalInternational Journal of Cancer
Issue number11
StatePublished - Jun 1 2013


  • HPV
  • cervical cancer
  • oncogenic risk
  • phylogeny
  • variant

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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