Genomic instability, aging, and cellular senescence

Rita A. Busuttil; Martijn Dollé; Judith Campisi; Jan Vijg

doi:10.1196/annals.1297.041

Genomic instability, aging, and cellular senescence

Rita A. Busuttil, Martijn Dollé, Judith Campisi, Jan Vijg

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Aging can be defined in practical terms as a series of time-related processes that ultimately bring life to a close. Genomic instability has been implicated as a major causal factor in aging. Here, we describe the use of a transgenic mouse model, harboring lacZ reporter genes as part of a plasmid construct integrated at one or more chromosomal locations, to study genomic instability during aging of different mouse organs and tissues as well as in mouse embryonic fibroblasts during primary culture.

Original language	English (US)
Pages (from-to)	245-255
Number of pages	11
Journal	Annals of the New York Academy of Sciences
Volume	1019
DOIs	https://doi.org/10.1196/annals.1297.041
State	Published - 2004
Externally published	Yes

Keywords

Aging
Cancer
DNA damage
Genomic integrity
Osidative damage

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1196/annals.1297.041

Cite this

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AU - Dollé, Martijn

AU - Campisi, Judith

AU - Vijg, Jan

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AB - Aging can be defined in practical terms as a series of time-related processes that ultimately bring life to a close. Genomic instability has been implicated as a major causal factor in aging. Here, we describe the use of a transgenic mouse model, harboring lacZ reporter genes as part of a plasmid construct integrated at one or more chromosomal locations, to study genomic instability during aging of different mouse organs and tissues as well as in mouse embryonic fibroblasts during primary culture.

KW - Aging

KW - Cancer

KW - DNA damage

KW - Genomic integrity

KW - Osidative damage

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ER -

Genomic instability, aging, and cellular senescence

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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