TY - JOUR
T1 - Genome instability and aging
T2 - Cause or effect?
AU - Vijg, Jan
AU - Montagna, Cristina
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/10
Y1 - 2017/10
N2 - Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal lineages, such as tumors, normal tissues have thus far not been amenable to mutation analysis except for the largest type of mutations: chromosomal aberrations. This is because mutations are random events and, therefore, unique to a single cell. New, single-cell sequencing-based methods are now emerging and may soon provide quantitative assays for estimating the possible functional effects of mutations accumulating during aging in various tissues and organs. Here we briefly review the mechanisms of genome instability in normal cells, the accumulation of various types of genome instability with age and their possible physiological consequences.
AB - Genome instability, i.e., the tendency of the genome to undergo alterations in DNA information content through mutation, is considered a hallmark of aging. While mutations can be analyzed in clonal lineages, such as tumors, normal tissues have thus far not been amenable to mutation analysis except for the largest type of mutations: chromosomal aberrations. This is because mutations are random events and, therefore, unique to a single cell. New, single-cell sequencing-based methods are now emerging and may soon provide quantitative assays for estimating the possible functional effects of mutations accumulating during aging in various tissues and organs. Here we briefly review the mechanisms of genome instability in normal cells, the accumulation of various types of genome instability with age and their possible physiological consequences.
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U2 - 10.1016/j.tma.2017.09.003
DO - 10.1016/j.tma.2017.09.003
M3 - Review article
AN - SCOPUS:85055877802
SN - 2468-5011
VL - 1
SP - 5
EP - 11
JO - Translational Medicine of Aging
JF - Translational Medicine of Aging
ER -