Genetic regulation of the embryology of the pituitary gland and somatotrophs

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Extrinsic and intrinsic signaling gradients determine expression patterns of pituitary-specific factors in the developing anterior pituitary gland. The temporal and spatial relations of these developmental factors are required for the determination of each of the pituitary cell lineages. Rpx is required for early differentiation of the anterior pituitary. The determination of the somatotroph cell line is dependent on the transcription factors Lhx3, Prop-1, and Pit-1. Pit-1 also plays a role in the activation and regulation of the somatotroph gene product, GH. Additional factors such as CREB and the GHRH receptor, may be involved in somatotroph determination, while Zn-15 and Pitx2 may be involved in GH gene activation.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
Issue number2
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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