Genetic causes of proteinuria and nephrotic syndrome: Impact on podocyte pathobiology

Oleh Akchurin, Kimberly J. Reidy

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


In the past 20 years, multiple genetic mutations have been identified in patients with congenital nephrotic syndrome (CNS) and both familial and sporadic focal segmental glomerulosclerosis (FSGS). Characterization of the genetic basis of CNS and FSGS has led to the recognition of the importance of podocyte injury to the development of glomerulosclerosis. Genetic mutations induce injury due to effects on the podocyte’s structure, actin cytoskeleton, calcium signaling, and lysosomal and mitochondrial function. Transgenic animal studies have contributed to our understanding of podocyte pathobiology. Podocyte endoplasmic reticulum stress response, cell polarity, and autophagy play a role in maintenance of podocyte health. Further investigations related to the effects of genetic mutations on podocytes may identify new pathways for targeting therapeutics for nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)221-233
Number of pages13
JournalPediatric Nephrology
Issue number2
StatePublished - Mar 2 2014


  • Focal segmental glomerulosclerosis
  • Genetic mutation
  • Nephrotic syndrome
  • Podocyte signaling
  • Steroid resistant nephrotic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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