Abstract
Heart failure with preserved ejection fraction is a distinct clinical entity with a unique pathophysiology. The prevalence increases with age, while the survival has remained stable. The treatment of comorbid conditions remains the cornerstone of therapy. Despite this, it is a highly morbid condition, with survival rates similar to heart failure with reduced ejection fraction. Exercise intolerance is a hallmark of the disease and is thought to be due to a complex interplay between endothelial dysfunction, neurohormonal disarray, and the periphery. No therapies to date have been shown to improve survival.
Original language | English (US) |
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Title of host publication | Diastology |
Subtitle of host publication | Clinical Approach to Heart Failure with Preserved Ejection Fraction |
Publisher | Elsevier |
Pages | 86-92 |
Number of pages | 7 |
ISBN (Electronic) | 9780323640671 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Diastolic heart failure
- Epidemiology
- HFpEF
- Pathophysiology
- Terminology
ASJC Scopus subject areas
- General Medicine