Gene therapy for psychiatric disorders

Yaroslav Gelfand, Michael G. Kaplitt

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Gene therapy has become of increasing interest in clinical neurosurgery with the completion of numerous clinical trials for Parkinson disease, Alzheimer disease, and pediatric genetic disorders. With improved understanding of the dysfunctional circuitry mediating various psychiatric disorders, deep brain stimulation for refractory psychiatric diseases is being increasingly explored in human patients. These factors are likely to facilitate development of gene therapy for psychiatric diseases. Because delivery of gene therapy agents would require the same surgical techniques currently being employed for deep brain stimulation, neurosurgeons are likely to lead the development of this field, as has occurred in other areas of clinical gene therapy for neurologic disorders. We review the current state of gene therapy for psychiatric disorders and focus specifically on particular areas of promising research that may translate into human trials for depression, drug addiction, obsessive-compulsive disorder, and schizophrenia. Issues that are relatively unique to psychiatric gene therapy are also discussed.

Original languageEnglish (US)
Pages (from-to)S32.e11-S32.e18
JournalWorld Neurosurgery
Issue number3-4
StatePublished - 2013
Externally publishedYes


  • AAV
  • Addiction
  • Adeno-associated virus
  • Area 25
  • Depression
  • Gene therapy
  • Infralimbic cortex
  • Nucleus accumbens
  • p11

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Gene therapy for psychiatric disorders'. Together they form a unique fingerprint.

Cite this