Gene targeting in mammalian cells by homologous recombination

Bernice Morrow, Raju Kucherlapati

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalCurrent Opinion in Biotechnology
Issue number5
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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