TY - JOUR
T1 - Gastrointestinal Symptoms in Children with an Autism Spectrum Disorder and Language Regression
AU - Valicenti-McDermott, Maria D.
AU - McVicar, Kathryn
AU - Cohen, Herbert J.
AU - Wershil, Barry K.
AU - Shinnar, Shlomo
N1 - Funding Information:
This project was supported in part by the Empire Research Fellowship for Clinical Investigation of New York State and the Albert Einstein College of Medicine Clinical Research Training Program Pilot Funding (M.D.V.-M.) and supported by National Institutes of Health grants K12 NS048856 from the National Institute of Neurological Disorders and Stroke and RR-17672-01 (K.M.).
PY - 2008/12
Y1 - 2008/12
N2 - Few studies have compared gastrointestinal problems in children with an autism spectrum disorder with and without a history of language regression. A cross-sectional study was conducted with structured interviews in 100 children with autism spectrum disorder, using a gastrointestinal questionnaire and a familial autoimmune questionnaire. By parental report, children with language regression more frequently exhibited an abnormal stool pattern (40% vs 12%, P = 0.006) and had an increased family history of celiac disease or inflammatory bowel disease (24% vs 0%, P = 0.001) and of rheumatoid arthritis (30% vs 11%, P = 0.03). Among 35 children with a family history of autoimmune disease, an abnormal stool pattern was reported more frequently in those with language regression (78% vs 15%, P = 0.001) than in those without. An association was observed between children with language regression, a family history of autoimmune disease, and gastrointestinal symptoms. Additional studies are needed to examine a possible shared autoimmune process.
AB - Few studies have compared gastrointestinal problems in children with an autism spectrum disorder with and without a history of language regression. A cross-sectional study was conducted with structured interviews in 100 children with autism spectrum disorder, using a gastrointestinal questionnaire and a familial autoimmune questionnaire. By parental report, children with language regression more frequently exhibited an abnormal stool pattern (40% vs 12%, P = 0.006) and had an increased family history of celiac disease or inflammatory bowel disease (24% vs 0%, P = 0.001) and of rheumatoid arthritis (30% vs 11%, P = 0.03). Among 35 children with a family history of autoimmune disease, an abnormal stool pattern was reported more frequently in those with language regression (78% vs 15%, P = 0.001) than in those without. An association was observed between children with language regression, a family history of autoimmune disease, and gastrointestinal symptoms. Additional studies are needed to examine a possible shared autoimmune process.
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U2 - 10.1016/j.pediatrneurol.2008.07.019
DO - 10.1016/j.pediatrneurol.2008.07.019
M3 - Article
C2 - 19027584
AN - SCOPUS:56249092126
SN - 0887-8994
VL - 39
SP - 392
EP - 398
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 6
ER -