Gastric cancer management: Kinases as a target therapy

Batoul Farran, Susanne Müller, Raquel C. Montenegro

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

The molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating ‘oncomaps’ for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminated in the approval of novel molecular therapies such as trastuzumab. Gastric tumours display recurrent aberrations in key kinase oncogenes such as Her2, epidermal growth factor receptor (EGFR), PI3K, mTOR or c-Met, suggesting that these receptors are amenable to inhibition using specific drug agents. In this review, we examine the mutational landscape of gastric cancer, the use of kinase inhibitors as targeted therapies in gastric tumours and the clinical trials underway for novel inhibitors, highlighting successes, failures and future directions.

Original languageEnglish (US)
Pages (from-to)613-622
Number of pages10
JournalClinical and Experimental Pharmacology and Physiology
Volume44
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • gastric cancer
  • kinases
  • monoclonal antibodies
  • precision medicine
  • small-molecule kinase inhibitors
  • targeted therapy

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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