Gap junctions in C. elegans: Their roles in behavior and development

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The nematode Caenorhabditis elegans utilizes gap junctions in different fashions in virtually all of its cells. This model animal has a surprisingly large number of innexin genes within its genome, and many nematode cell types can express multiple innexins at once, leading to the formation of diverse junction types and enough redundancy to limit the effect of single gene knockdowns on animal development or behavioral phenotypes. Here, we review the general properties of these junctions, their expression patterns, and their known roles in tissue development and in the animal's connectome.

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
JournalDevelopmental Neurobiology
Issue number5
StatePublished - May 2017


  • heteromeric
  • heterotypic
  • innexin
  • nematode

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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