TY - JOUR
T1 - Gap junctional conductance
T2 - Comparison of sensitivities to H and Ca ions
AU - Spray, D. C.
AU - Stern, J. H.
AU - Harris, A. L.
AU - Bennett, Michael V. L.
PY - 1982
Y1 - 1982
N2 - One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.
AB - One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.
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U2 - 10.1073/pnas.79.2.441
DO - 10.1073/pnas.79.2.441
M3 - Article
C2 - 6281771
AN - SCOPUS:0020027771
SN - 0027-8424
VL - 79
SP - 441
EP - 445
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 2 I
ER -