Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Steven M. Wolf; Shlomo Shinnar; Harriet Kang; Karen Ballaban Gil; Solomon L. Moshé

doi:10.1111/j.1528-1157.1995.tb01063.x

Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Steven M. Wolf, Shlomo Shinnar, Harriet Kang, Karen Ballaban Gil, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

Original language	English (US)
Pages (from-to)	1203-1205
Number of pages	3
Journal	Epilepsia
Volume	36
Issue number	12
DOIs	https://doi.org/10.1111/j.1528-1157.1995.tb01063.x
State	Published - Dec 1995

Keywords

Anticonvulsants
Children's behavioral events
Gabapentin

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1157.1995.tb01063.x

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AB - Summary: Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We describe 3 learning disabled children, 1 aged 7 years and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outbursts consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

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Gabapentin Toxicity in Children Manifesting as Behavioral Changes

Abstract

Keywords

ASJC Scopus subject areas

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