Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats

Jana Velísková; Douglas S. Garant; Shu G. Xu; Solomon L. Moshé

doi:10.1016/0165-3806(94)90135-X

Further evidence of involvement of substantia nigra GABA_B receptors in seizure suppression in developing rats

Jana Velísková, Douglas S. Garant, Shu G. Xu, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABA_B receptor activation, we tested the effects of intranigral CGP 35 348 (a GABA_B receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABA_B receptors regulate, in part, flurothyl-induced seizures.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Developmental Brain Research
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(94)90135-X
State	Published - Jun 17 1994

Keywords

Development
Rat
Seizures
Substantia nigra
γ-Aminobutyric acid
γ-Aminobutyric acid receptor

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(94)90135-X

Cite this

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title = "Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats",

abstract = "To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35 348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABAB receptors regulate, in part, flurothyl-induced seizures.",

keywords = "Development, Rat, Seizures, Substantia nigra, γ-Aminobutyric acid, γ-Aminobutyric acid receptor",

author = "Jana Vel{\'i}skov{\'a} and Garant, {Douglas S.} and Xu, {Shu G.} and Mosh{\'e}, {Solomon L.}",

note = "Funding Information: Supported by NIH Grant NS-20253 and NRSA training grant NS-07183 from the NINDS. GVG was a generous gift from Marion-Merrell-Dow Research (Kansas City, MO, USA) and CGP 35 348 generous gift from Ciba-Geigy (Basel. Switzerland).",

year = "1994",

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doi = "10.1016/0165-3806(94)90135-X",

language = "English (US)",

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AU - Velísková, Jana

AU - Garant, Douglas S.

AU - Xu, Shu G.

AU - Moshé, Solomon L.

N1 - Funding Information: Supported by NIH Grant NS-20253 and NRSA training grant NS-07183 from the NINDS. GVG was a generous gift from Marion-Merrell-Dow Research (Kansas City, MO, USA) and CGP 35 348 generous gift from Ciba-Geigy (Basel. Switzerland).

PY - 1994/6/17

Y1 - 1994/6/17

N2 - To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35 348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABAB receptors regulate, in part, flurothyl-induced seizures.

AB - To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35 348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35 348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35 348 did not alter seizure thresholds. The data suggest that, in rat pups, nigra-GABAB receptors regulate, in part, flurothyl-induced seizures.

KW - Development

KW - Rat

KW - Seizures

KW - Substantia nigra

KW - γ-Aminobutyric acid

KW - γ-Aminobutyric acid receptor

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