Fundamentals of MRI for assessing brain function and metabolism

William A. Gomes, Michael L. Lipton

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Introduction Modern neuroimaging has revolutionized the study of brain structure and function. In particular, advanced magnetic resonance imaging (MRI) techniques allow the non-invasive collection of functional and metabolic data in human subjects that were previously restricted to invasive animal model systems. In this chapter, we review three of the most important and topical advanced MRI techniques. We first consider functional MRI (fMRI), which permits dynamic evaluation of neural activity in specific brain regions. Numerous applications for fMRI exist in sleep-related research, including examination of the neural correlates of sleep states and the consequences of sleep disturbance for waking neural function [1]. We then discuss diffusion tensor imaging (DTI), which illuminates the structure of cerebral white matter, and demonstrates the white matter connections between gray matter structures. DTI may thereby allow the identification of subtle white matter abnormalities which contribute to sleep-related disorders [2, 3]. We conclude with an introduction to magnetic resonance spectroscopy (MRS), a non-invasive method for the evaluation of brain chemistry. MRS may permit the demonstration of subtle metabolic deficits that accompany sleep disturbance [4, 5].

Original languageEnglish (US)
Title of host publicationNeuroimaging of Sleep and Sleep Disorders
PublisherCambridge University Press
Number of pages9
ISBN (Electronic)9781139088268
ISBN (Print)9781107018631
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Medicine(all)


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