Abstract
Highly functionalized Grignard-reagents can be easily obtained by an iodine-magnesim exchange reaction and further reacted with various electrophiles. Via a B-Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.
Original language | English (US) |
---|---|
Pages (from-to) | 11-17 |
Number of pages | 7 |
Journal | Pure and Applied Chemistry |
Volume | 74 |
Issue number | 1 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering