Abstract
OBJECTIVE: Evaluate functional changes after botulinum
toxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlled
trial comparing three injection techniques of BTX-A
in spasticity, we used the Modified Frenchay Scale to assess
20 hemiplegic patients before and 1 month after an injection
of 160 units of BTX-A (Botox) into spastic biceps brachii.
Subjects were videotaped performing four unimanual and six
bimanual upper limb activities (picking up a cup, using a
comb, etc.). A blinded reviewer rated the performances on a
visual analog scale from 1 to 10. RESULTS: Functional performance
was significantly enhanced by a mean of 5% ( p
0.015; paired t-test). Mean improvement was 9% on unimanual
tasks ( p 0.06) and 2% on bimanual tasks (NS).
Individual task analysis showed significant improvement in
three tasks ( p 0.05), two of which were unimanual reaching
movements. CONCLUSION: A single injection of
BTX-A into biceps brachii was associated with upper limb
functional improvements in hemiparetic patients, particularly
in unimanual reaching activities. Functional scales using
blinded video assessments may be useful for detecting
changes after intervention in hemiplegia. Study supported by
Allergan. Jean-Michel Gracies received a research grant and
speaking honoraria from Allergan. David M. Simpson received
a research grant and speaking honoraria from Allergan.
toxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlled
trial comparing three injection techniques of BTX-A
in spasticity, we used the Modified Frenchay Scale to assess
20 hemiplegic patients before and 1 month after an injection
of 160 units of BTX-A (Botox) into spastic biceps brachii.
Subjects were videotaped performing four unimanual and six
bimanual upper limb activities (picking up a cup, using a
comb, etc.). A blinded reviewer rated the performances on a
visual analog scale from 1 to 10. RESULTS: Functional performance
was significantly enhanced by a mean of 5% ( p
0.015; paired t-test). Mean improvement was 9% on unimanual
tasks ( p 0.06) and 2% on bimanual tasks (NS).
Individual task analysis showed significant improvement in
three tasks ( p 0.05), two of which were unimanual reaching
movements. CONCLUSION: A single injection of
BTX-A into biceps brachii was associated with upper limb
functional improvements in hemiparetic patients, particularly
in unimanual reaching activities. Functional scales using
blinded video assessments may be useful for detecting
changes after intervention in hemiplegia. Study supported by
Allergan. Jean-Michel Gracies received a research grant and
speaking honoraria from Allergan. David M. Simpson received
a research grant and speaking honoraria from Allergan.
| Original language | English (US) |
|---|---|
| Pages | S72-S72 |
| State | Published - Aug 31 2004 |
| Event | American Neurological Association: 2004 Annual Meeting - Toronto, Canada Duration: Oct 3 2004 → Oct 6 2004 |
Conference
| Conference | American Neurological Association: 2004 Annual Meeting |
|---|---|
| Country/Territory | Canada |
| City | Toronto |
| Period | 10/3/04 → 10/6/04 |